Journal of Applied Science and Engineering

Published by Tamkang University Press

1.30

Impact Factor

2.10

CiteScore

Chih-Sheng Yu This email address is being protected from spambots. You need JavaScript enabled to view it.1, Ming-Yu Lin1, Heng-Tsang Hu1, Yi-Chiuen Hu1 and Haiao-Yu Chou1

1Instrument Technology Research Center, National Applied Research Laboratories Hsinchu, Taiwan 300, R.O.C.


 

Received: January 15, 2005
Accepted: June 2, 2005
Publication Date: September 1, 2005

Download Citation: ||https://doi.org/10.6180/jase.2005.8.3.06  


ABSTRACT


We characterize a droplet-based biochemical reaction device with the features of droplet self-positioning, self-mixing and self-alignment optics on a micro-patterning PDMS chip. The phenomenon of droplet self-positioning is explained as follows: the different texture zones generate gradient of surface tension force to manipulate droplet. Droplet-based reagents can be transported, precisely positioning, and mixed on the detection zone without any power source. The study was carried out to experimentally determined triglycerides (TG) using this droplet manipulation device with correlation coefficient 0.922 from 19 mg/dl to 480 mg/dl.


Keywords: Droplet Manipulation, Droplet Self-mixing, Triglycerides Assay


REFERENCES


  1. [1] American Heart Association, http://www.americanheart. org.
  2. [2] Lchimura, K., Oh, S. k. and Nakagawa, M., “Lightdriven Motion of Liquids on Photoresponsive Surface,” Science, Vol. 288, pp. 16241626 (2000).
  3. [3] Valentino, J. P., Wagner, S. and Troian, S. M., “Thermocapillary Actuatuin of Liquids Using Patterned Microheater Arrays,” Transducer, pp. 667669 (2003).
  4. [4] Fan, S. K., Hashi, C. and Kim, C. J., “Manipulation of Multiple Droplets on MxN Grid by Cross-reference EWOD Driving Scheme and Pressure-contact Packaging,” IEEE Conf. MEMS, pp. 694697 (2003).
  5. [5] Miwa, M., Nakajima, A., Fujishima, A., Hashimoto, K., Watanabe, T., “Effect of the Surface Roughness on Sliding Angle of Water Droplets on Superhydrophobic Surfaces,” Langmuir, Vol. 16, pp. 57545760 (2000).
  6. [6] He, B. and Lee J., “Dynamic Wettability Switching by Surface Roughness Effect,” IEEE Conf. MEMS, pp. 120123 (2003).
  7. [7] Cassie, A. B. D. and Baxter, 1944, “Wettability of Porous Surfaces,” Transactions of the Faraday Society, Vol. 40, pp. 546551.
  8. [8] Adamson, W. Physical Chemistry of Surfaces, Fifth Edition, Wiley-Interscience, NY, U.S.A. (1990).
  9. [9] Chen, W., Fadeev, A. Y., Hsieh, M. C., Oner, D., Youngblood, J. and McCarthy, T. J., “Ultrahydrophobic and Ultralyophobic Surface: Some Comments and Examples,” Langumir, Vol. 15, pp. 33953399 (1999).
  10. [10] Verdier, C., “The Influence of he Viscosity Ratio on Polymer Droplet Collision in Quiescent Blends,” Polymer, Vol. 42, pp. 69997007 (2001).
  11. [11] Tice, J. D., Song, H., Lyon, A. D. and Ismagilov, R. F., “Formation of Droplets and Mixing in Multiphase Microfluidics at Low Values of the Reynolds and the Capillary Numbers,” Langmuir, Vol. 19, pp. 91279133 (2003).
  12. [12] Paik, P., Pamula, V. K., Pollack, M. G. and Fair, R. B., “Electrowetting-based Droplet Mixers for Microfluidics System,” Lab-on-a-chip, Vol. 3, pp. 2833 (2003).
  13. [13] Fowler, J., Moon, H., Kim, C. J., “Enhancement of Mixing by Droplet-based Microfluidics,” IEEE Conf. MEMS, pp. 97100 (2002).