Transforming Otilonium Bromide for Resilient Antimicrobial Combat

Joanna  Antos; Daria  Wieczorek; Katarzyna  Staszak; Yuk-Ping  Chou; Li-Hang  Hsu; Tang-Long  Shen; Ying-Lien  Chen

doi:10.6180/jase.202510_28(10).0012

Transforming Otilonium Bromide for Resilient Antimicrobial Combat

Chemical Engineering Environmental Engineering

Joanna Antos^1,2, Daria Wieczorek²This email address is being protected from spambots. You need JavaScript enabled to view it., Katarzyna Staszak³, Yuk-Ping Chou⁴, Li-Hang Hsu⁴, Tang-Long Shen⁴, and Ying-Lien Chen⁴This email address is being protected from spambots. You need JavaScript enabled to view it.

¹Department of Water Supply and Bioeconomy, Faculty of Environmental Engineering and Energy, Poznan University of Technology, Berdychowo 4, 60-965 Poznan, Poland

²Department of Instrumental Technology and Analysis, Poznan University of Economics and Business, 61-875 Poznan, Poland

³Institute of Chemical Technology and Engineering, Faculty of Chemical Technology, Poznan University of Technology, ul. Berdychowo 4, 60-965 Poznan, Poland

⁴Department of Plant Pathology and Microbiology, National Taiwan University, Taipei, Taiwan

Received: July 29, 2024
Accepted: December 17, 2024
Publication Date: January 24, 2025

Copyright The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cited.

Download Citation: ||https://doi.org/10.6180/jase.202510_28(10).0012

Otilonium bromide is a cationic surfactant with established medical applications, revealing a promising dimension in its versatile nature. Beyond its conventional use, the compound demonstrates notable antifungal properties, signaling a substantial extension of its application potential. Due to the spreading drug resistance of many microorganisms to active substances and antibiotics, it is necessary to search for and create new compounds that will exhibit more aggressive mechanisms of action. Based on the methods of synthesis of otilonium bromide, new derivatives of the compound were created to broaden its applicability beyond its traditional pharmaceutical utility. Delving into the intricate synthesis processes employed, this study provides a detailed exploration of the newly created derivatives of otilonium bromide. The broadening of the applicability of otilonium bromide, especially in response to emerging challenges posed by microbial resistance, is intended to make a significant contribution to the evolving landscape of antimicrobial therapeutics. The findings not only unveil the expanded capabilities of otilonium bromide but also reveal new avenues for the development of compounds with enhanced efficacy and resilience in combating microbial threats.

Keywords: otilonium bromide; cationic surfactants; drugs; antifungal properties; quaternary compounds

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